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ea0090rc9.1 | Rapid Communications 9: Adrenal and Cardiovascular Endocrinology 2 | ECE2023

Symptoms of glucocorticoid-induced adrenal insufficiency – A systematic evaluation of clinician- and patient-reported symptoms and their rated relevance

Lund Marie Louise , Bjorner Jakob Bue , Al-Jorani Hajir , Boesen Victor Brun , Dreyer Anja Fenger , Boggild Hansen Simon , Jorgensen Nanna Thurmann , Klose Marianne , Tei Randi , Watt Torquil , Feldt-Rasmussen Ulla , Borresen Stina Willemoes

Context: Glucocorticoid-induced adrenal insufficiency is the most frequent type of adrenal insufficiency, but its symptomatology has not been thoroughly studied.Objective: To describe the predominant symptoms experienced by patients with glucocorticoid-induced adrenal insufficiency and rate these symptoms significance for patients perceived need for supplemental hydrocortisone stress dose.Methods: The 80 symptoms in the...

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ea0090rc9.5 | Rapid Communications 9: Adrenal and Cardiovascular Endocrinology 2 | ECE2023

Higher maternal cortisol associated with lower blood pressure in offspring from 3 months to 5 years of age in the odense child cohort

Al-Jorani Hajir , Christian Jensen Richard , Jonasson Mikaela , Birukov Anna , Schmedes Anne Vibeke , Christesen Henrik Thybo , Dreyer Anja Fenger , Jensen Tina Kold , Glintborg Dorte , Jensen Boye Lagerbon , Andersen Marianne

Background: Synthetic glucocorticoid exposure in late pregnancy may be associated with higher blood pressure in offspring. We hypothesized that endogenous cortisol in pregnancy relates to offspring blood pressure (OBP).Objective: To investigate associations between maternal cortisol status in 3rd trimester pregnancy and OBP.Methods: We included 1,317 mother-child pairs from Odense Child Cohort (OCC), an observational prospective co...

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ea0090ep23 | Adrenal and Cardiovascular Endocrinology | ECE2023

REPLACE: Effect of hydrocortisone and placebo in patients with partial adrenal insufficiency after cessation of glucocorticoid treatment; A study protocol for a multi-centre, randomised, double-blinded, placebo-controlled clinical trial

Dreyer Anja Fenger , Borresen Stina Willemoes , Hansen Simon Boggild , Al-Jorani Hajir , Bislev Lise Sofie , Boesen Victor Brun , Christensen Louise Lehmann , Glintborg Dorte , Jensen Richard Christian , Jorgensen Nanna Thurmann , Klose Marianne , Lund Marie Louise , Stankovic Jelena , Tei Randi , Watt Torquil , Feldt-Rasmussen Ulla , Jorgensen Jens Otto , Andersen Marianne

Background: Glucocorticoid (GC) formulations are widely used as anti-inflammatory treatment, and synthetic GC, e.g. prednisolone, is the cornerstone treatment of polymyalgia rheumatic (PMR) and giant cell arteritis (GCA). Long-term pharmacological GC treatment may induce adrenal insufficiency (GIA). Adrenal function is, however, not routinely assessed after discontinuation of long-term GC treatment, and it is unknown, if hydrocortisone replacement is beneficial. This study aim...

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Endocrine Abstracts

Symptoms of glucocorticoid-induced adrenal insufficiency – A systematic evaluation of clinician- and patient-reported symptoms and their rated relevance

Higher maternal cortisol associated with lower blood pressure in offspring from 3 months to 5 years of age in the odense child cohort

REPLACE: Effect of hydrocortisone and placebo in patients with partial adrenal insufficiency after cessation of glucocorticoid treatment; A study protocol for a multi-centre, randomised, double-blinded, placebo-controlled clinical trial

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